Abstract
Background:
The Institute of Medicine (IOM) dietary guidelines for vitamin D are based on limited pediatric data. Our objective was to estimate the dietary vitamin D requirements for maintaining serum 25-hydroxyvitamin D [25(OH)D] concentrations at the various IOM-considered thresholds of vitamin D status (12, 16, and 20 ng/ml) during fall and winter in children.
Methods:
Ninety-six healthy 8- to 14-y-old Pittsburgh-area black and white children enrolled in a randomized, placebo-controlled trial of vitamin D3 1,000 IU daily for 6 mo with baseline and 2-mo follow-up assessments completed during October through April were studied. Vitamin D intake from diet and study supplement adjusted for adherence and serum 25(OH)D were measured.
Results:
The vitamin D intakes needed to maintain serum 25(OH)D concentrations at 12, 16, and 20 ng/ml in 90% of the children were 581, 1,062, and 1543 IU/day, respectively. The estimated vitamin D intakes needed to maintain serum 25(OH)D concentrations at 20 ng/ml in 97.5% of the children was 2,098 IU/day.
Conclusion:
Our data suggest that the current vitamin D recommended dietary allowance (RDA) (600 IU/day) is insufficient to cover the skeletal health needs of at least 50% of black and white children.
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Acknowledgements
K.R., C.G.M., and J.Y.: conceptualized and designed the study; K.R., F.O., and M.A.H.: conducted the research and obtained the data; C.G.M. and J.Y.: performed the statistical analysis; K.R., C.G.M., S.L.G., M.F.H., and J.Y.: interpreted the data; M.F.H.: performed the 25(OH)D assay; K.R., C.G.M., J.Y., and D.C.: drafted the manuscript; All authors: critically revised the manuscript; K.R.: secured funding and supervised the study. K.R. had full access to all of the data in this study and takes responsibility for the integrity and accuracy of this work as a whole from inception to publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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Rajakumar, K., Moore, C., Yabes, J. et al. Estimations of dietary vitamin D requirements in black and white children. Pediatr Res 80, 14–20 (2016). https://doi.org/10.1038/pr.2016.46
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DOI: https://doi.org/10.1038/pr.2016.46
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