Abstract
Background
To determine the predictors of achieving independent walking at 2 and 6 months after onset of weakness in children with Guillain-Barre syndrome (GBS).
Methods
Children with GBS admitted to the Tabriz Children’s Hospital were studied prospectively. All patients had frequent clinical evaluations until achieving independent walking. Unaided walking at 2 and 6 months and factors influencing these outcomes were determined using both univariate and multiple analyses.
Results
Between 2003 and 2014, 324 children (mean age: 5.3±3.66 years) were admitted. The mean duration to independent walking was 2.97±3.02 months; 90.5% of patients could walk independently at 6 months. In the univariate analysis, disability score of >3 (P=0.03), autonomic nerve involvement (P=0.003), cranial nerve involvement (P=0.008), and absent compound muscle action potential (CMAP; P=0.048) were found to be significantly associated with poor walking outcome at 6 months. In the multivariate analysis, cranial nerve involvement (P=0.008) and absence of CMAP (P=0.022) were independently associated with poor functional outcome.
Conclusion
Disability score >3, cranial and autonomic nerve involvement, and absence of CMAP were predictors of independent walking in childhood GBS in this study; early rehabilitation program may prevent further impairments secondary to immobility in these patients.
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Acknowledgements
This research was supported by the Pediatric Health Research Center and Physical Medicine and Rehabilitation Research Center in Tabriz Medical Science University. We are especially grateful to the patients and their parents for participation and cooperation in this research. We take responsibility for the integrity and accuracy of the data.
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This study was financially supported and conducted under the supervision of “Pediatric Health Research Center” and “Physical Medicine and Rehabilitation Research Center” of Tabriz University of Medical Sciences, related to government.
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Barzegar, M., Toopchizadeh, V., Maher, M. et al. Predictive factors for achieving independent walking in children with Guillain-Barre syndrome. Pediatr Res 82, 333–339 (2017). https://doi.org/10.1038/pr.2017.67
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DOI: https://doi.org/10.1038/pr.2017.67
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