Abstract
Background
We intended to evaluate the effects of physical activity (PA) programs on renal function in obese boys.
Methods
Thirty-nine boys participated in one of the following three groups: soccer (SG, n=13), traditional PA (AG, n=13), and sedentary control (CG, n=13). SG and AG were involved in 6-month PA programs, involving three sessions/week for 60–90 min. Anthropometric measurements, body composition, creatinine and cystatin C plasmatic levels, and estimated glomerular filtration rate (eGFR) were evaluated.
Results
At baseline (n=39), age and lean mass index (LMI) were positively correlated with creatinine levels. After 6 months, both intervention groups decreased the BMI z-score and waist circumference, while the CG increased the body fat percentage (BFP). LMI increased in all the groups. SG presented a small increment in plasma creatinine and a decrease in the eGFR values, using the Schwartz formula. Concerning the cystatin C levels and eGFR values using Filler (cystatin C-based) or Combined Zappitelli (creatinine/cystatin C-based) formulas, no significant changes were observed in any group.
Conclusion
The combined Zappitelli formula showed no significant impact of PA on eGFR in obese boys. Although plasma creatinine is significantly influenced by lean body mass, cystatin C is likely to be a more accurate marker of renal function in this population.
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STATEMENT OF FINANCIAL SUPPORT
This work received financial support from the Union European Football Association (UEFA), the Portuguese Football Federation (FPF), the European Union (FEDER funds POCI/01/0145/FEDER/007728), National Funds (FCT/MEC, Fundação para a Ciência e Tecnologia and Ministério da Educação e Ciência) under the Partnership Agreement PT2020 UID/MULTI/04378/2013, and Norte Portugal Regional Coordination and Development Commission (CCDR-N)/NORTE2020/Portugal 2020 (Norte-01-0145-FEDER-000024). We also thank the following support: UID/NEU/04539/2013, FCOMP-01-0124-FEDER-028417, and POCI-01-0145-FEDER-007440, as well as CENTRO-01-0145-FEDER-000012.
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Lousa, I., Nascimento, H., Rocha, S. et al. Influence of the 6-month physical activity programs on renal function in obese boys. Pediatr Res 83, 1011–1015 (2018). https://doi.org/10.1038/pr.2018.15
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DOI: https://doi.org/10.1038/pr.2018.15
