Table 5 The interactive effects of chromosomal abnormality and genetic mutations on recurrent spontaneous abortion development

Rs	Genotype	Chromosome	Case	Control	OR	95% CI	P-value	Regression of efficient		γ-value
								β_e	β_eg
rs231775	AA	Normal	633	411	Ref.			0.00
	AG	Normal	495	483	0.67	0.56–0.79	1.57 × 10 ⁻⁴	–0.40
	GG	Normal	96	142	0.44	0.33–0.59	3.14 × 10 ⁻⁷	–0.82
	AA	Abnormal	31	4	5.03	1.76–14.36	8.32 × 10 ⁻⁴	0.00	1.62
	AG	Abnormal	24	5	3.12	1.18–8.24	0.02	–0.40	1.14	–2.85
	GG	Abnormal	5	1	3.25	0.38–27.90	0.26	–0.82	1.18	–1.43
rs3087243	GG	Normal	71	150	Ref.			0.00
	GA	Normal	446	488	1.93	1.42–2.63	7.18 × 10 ⁻⁴	0.66
	AA	Normal	707	398	3.75	2.76–5.11	4.45 × 10 ⁻¹⁷	1.32
	GG	Abnormal	3	1	6.34	0.65–62.04	0.07	0.00	1.85
	GA	Abnormal	22	5	9.30	3.38–25.56	1.54 × 10 ⁻⁵	0.66	2.23	3.38
	AA	Abnormal	35	4	18.49	6.33–54.03	3.97 × 10 ⁻¹⁰	1.32	2.92	2.21
rs2232365	AA	Normal	311	289	Ref.			0.00
	AG	Normal	411	364	1.05	0.85–1.30	0.66	0.05
	GG	Normal	502	382	1.22	0.99–1.50	0.06	0.20
	AA	Abnormal	15	3	4.65	1.33–16.22	8.35 × 10 ⁻³	0.00	1.54
	AG	Abnormal	20	4	4.65	1.57–13.76	2.43 × 10 ⁻³	0.05	1.54	30.8
	GG	Abnormal	25	3	7.74	2.31–25.93	2.78 × 10 ⁻³	0.20	2.05	10.25
rs2232368	GG	Normal	664	546	Ref.			0.00
	GA	Normal	413	405	0.84	0.70–1.01	0.05	–0.17
	AA	Normal	147	85	1.42	1.06–1.90	0.02	0.35
	GG	Abnormal	33	5	5.43	2.10–14.00	2.52 × 10 ⁻³	0.00	1.69
	GA	Abnormal	20	5	3.29	1.23–8.82	0.01	−0.17	1.19	−7.00
	AA	Abnormal	7	0	—	—	—

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