Fig. 2
From: Lifestyles, genetics, and future perspectives on gastric cancer in east Asian populations
Mutational signatures in the cancer genome. The somatic mutation profile in an individual gastric cancer genome (center) can be mathematically factorized into cumulative combinations of mutational signatures (outer graphs). To date, more than 60 mutational signatures have been proposed by COSMIC, several of which are linked to specific carcinogenic factors (smoking, alcohol use, ultraviolet exposure, ageing, etc.). By calculating the contribution score for each mutational signature (α, β, γ, etc.), the relative contributions of the causative factors to carcinogenesis can precisely be estimated. Graphs of the mutational signatures are derived from COSMIC website (Mutational Signatures v2, https://cancer.sanger.ac.uk/cosmic/signatures_v2.tt)
