Table 2 Summary of the loci and genes of the three models
From: Host genetic factors of COVID-19 susceptibility and disease severity in a Thai population
Model | Phenotypic impact | Chromosome | Position | p value | Odds ratio or Effect size | Genes in the significant block | Genes in extended of the significant block |
|---|---|---|---|---|---|---|---|
Model 1 | Susceptibility | 5 | 148710242–148768047 | 6.8745 × 10−6 × 6.8755 × 10−6 | Odds ratio 0.02 | AFAP1L1 GRPEL2 PCYOX1L IL17B | ABLIM3, BX640700 CSNK1A1 L26953 MIR143 |
9 | 77748151–77762449 | 2.3197 × 10−6 – 9.5083 × 10−6 | Odds ratio 0.11–0.13 | OSTF1 | C9orf41 BC043649 NMRK1 | ||
Model 2 | Severity I | 12 | 93426633–93446082 | 1.3490 × 10−6 – 4.3527 × 10−6 | Odds ratio 0.28–0.31 | LOC643339 | EEA1, LINC02412 |
Model 3 | Severity II | 3 | 21141028–21235640 | 5.0649 × 10−7 – 2.5343 × 10−6 | Effect size 1.60–1.73 | – | VENTXP, ZNF385D |
