Fig. 1: Clinical manifestations, family information, and Sanger sequencing results.
From: DNA2 mutation causing multisystemic disorder with impaired mitochondrial DNA maintenance
A, B Bilateral excessive bending of the fingers and toes; C pes cavus. D high arch of the hard palate and irregular tooth arrangement. E Family pedigree; the father had the same phenotype, but a genetic analysis was not performed. F Patient heterozygous DNA2 variant verified via Sanger sequencing. G A Normative control of the gene
