Fig. 1

Box plot and cumulative frequency histogram of the onset age of extramuscular symptoms in FSHD1 patients and non-affected (non-FSHD1) individuals. A Among FSHD1 patients, 10 patients had diabetes mellitus within their fifth and sixth decades, while none did among non-FSHD1 individuals. B Hyperlipidemia was observed in 18 FSHD1 patients, but not in non-FSHD1 individuals. The number of FSHD1 patients with hyperlipidemia increased after the age of 30 years. C Cardiovascular events occurred in 8 FSHD1 patients in their fifth and sixth decades, but not in non-FSHD1 individuals. D Gastrointestinal cancers (gastric and colorectal cancers) also increased after the age of 40 years and were more frequently observed in FSHD1 patients (10 patients vs 2 non-FSHD1 individuals). E Colorectal cancers were observed in eight FSHD1 patients and two non-affected individuals after the age of 40 years. However, there was no significant difference in the number of colorectal cancers