Fig. 4 | Journal of Human Genetics

Fig. 4

From: Association study of GBA1 variants with MSA based on comprehensive sequence analysis -Pitfalls in short-read sequence analysis depending on the human reference genome-

Fig. 4

Forest plot showing the results of the meta-analysis of the association of p.L483P with MSA. The forest plot shows the results of the meta-analysis of the association of p.L483P with MSA combining the current study and the previous report [10]. Squares and horizontal lines represent estimated ORs and 95% CIs for individual series. The size of each square represents the statistical weight, the mean of the effect sizes using the inverse variance of the individual studies. Diamonds show the overall effects with 95% CIs. Since between-study variability was not observed (I2 = 0%, τ2 = 0, p =0.87), the common effects model was employed for the meta-analysis, which demonstrated the odds ratio of 2.85 (95% CI; 1.05 – 7.76, p = 0.0400), indicating that the allele frequency of p.L483P is significantly higher in MSA than in control samples in the Japanese population

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