Fig. 3 | Journal of Human Genetics

Fig. 3

From: Healthy lifestyle practice correlates with decreased obesity prevalence in individuals with high polygenic risk: TMM CommCohort study

Fig. 3

Model validation. Normalized PGSs in three validation datasets exhibited a similar distribution (p > 0.05 in the F-test comparing the distribution of each dataset to the pool of all validation samples) (A). The obesity prevalence, which was adjusted to the baseline (1st percentile) prevalence of zero, increased with elevation of the PGS percentile (B). The OR for obesity risk was determined by the low polygenic risk group (percentile 1–10) as reference (C). The fixed effect model was used for the meta-analysis. The error bars indicate the 95% confidence interval. OR odds ratio, PGS polygenic score, TMM Tohoku Medical Megabank

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