Table 1 Characteristics of the study population
TMM10K (model selection) | TMM67K (validation) | TMM18K (validation) | TMM8K (validation) | |
|---|---|---|---|---|
n | 9811 | 50195 | 11947 | 6796 |
Female, % | 65.2 | 60.9 | 75.6 | 66.8 |
Age, years | 60.6 ± 11.2 | 60.4 ± 11.3 | 58.0 ± 12.9 | 55.7 ± 13.5 |
BMI, kg/m2 | 23.6 ± 3.6 | 23.5 ± 3.6 | 22.8 ± 3.5 | 23.3 ± 3.6 |
Waist circumference, cm | 82.7 ± 9.4 (29) | 83.0 ± 9.4 (112) | 83.2 ± 9.7 (38) | 83.4 ± 9.7 (15) |
VFA (CT), cm2 | n.d. | n.d. | n.d. | 59.5 ± 32.4 (77) |
Body fat rate (BIA), % | n.d. | n.d. | 29.1 ± 7.7 (1) | n.d. |
Obesity (BMI), % | 30.6 | 30 | 23.2 | 27.7 |
Obesity (Waist), % | 28.1 (29) | 29.6 (112) | 30.1 (38) | 32.3 (15) |
Obesity (VFA), % | n.d. | n.d. | n.d. | 11.5 (77) |
Obesity (BIA), % | n.d. | n.d. | 59.5 (1) | n.d. |
LTE, MET-h/d | 2.6 ± 4.0 (3191) | 2.8 ± 4.2 (13116) | 2.7 ± 3.8 (778) | 2.0 ± 3.3 (269) |
DLA, MET-h/d | 22.6 ± 14.1 (3191) | 23.5 ± 14.8 (13116) | 20.1 ± 11.7(778) | 21.9 ± 12.9 (269) |
Sodium intake, g/d | 4.1 ± 0.9 (13) | 4.0 ± 0.9 (85) | 3.8 ± 0.9 (10) | 4.1 ± 0.9 (3) |
Array | OEE | JPAv2 | JPAv2 | JPAv2 |
Residencya | Iwate and Miyagi | Iwate and Miyagi | Miyagi | Iwate |
Recruited | Health checkup in local government | Health checkup in local government | Visited an assessment center in TMM | Visited an assessment center in TMM |
Allele count in PGS estimationb | 9996136 | 9989402 | 9991396 | 9987906 |
PGS [95%CI]b,c,d | –1.983 × 10–7 [–1.989 × 10–7 to –1.978 × 10-7] | –1.964 × 10–7 [–1.966 × 10–7 to –1.961 × 10–7] | –1.940 × 10–7 [–1.946 × 10–7 to –1.935 × 10-7] | –1.945 × 10–7 [–1.953 × 10–7 to –1.938 × 10-7] |
