Fig. 4 | Journal of Human Genetics

Fig. 4

From: The usefulness of comprehensive genome profiling test in screening of Lynch syndrome independent of the conventional clinical screening or microsatellite instability tests

Fig. 4

The association between microsatellite status and variant of mismatch repair gene (A) Venn diagram for microsatellite instability-high (MSI-H) and mismatch repair (MMR) gene variants in 1583 patients who underwent comprehensive genomic profiling tests (CGP) tests in Hiroshima University Hospital and the cooperative hospitals between January 2020 and April 2024. Percentages in the figures indicate the proportion in the 1583 patients. B Boxplots of MANTIS scores (y-axes) by the presence or absence of MMR gene variant (x-axes) in thirty types of cancers in The Cancer Genome Atlas (TCGA), Pancancer atlas dataset. Horizontal dashlines indicate 0.4 which is cut-off value of MANTIS score to determine microsatellite status (MSI-H ≥ 0.4 and MSS < 0.4) Wilcoxon’s rank-sum tests were performed and p values less than 0.05 were considered statistically significant. In the figure, the corresponding p values which were statistically significant are shown with individual boxplots

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