Table 2 Summary of patients with Lynch syndrome who developed lung cancer
Case | Age | Sex | Other cancer(age) | Family history(age) | NGS test | MSI-test | MMR-IHC | MMR gene | Genes with somatic mutations | Genetic testing of relatives | Author year |
1 | 58 | M | Colorectum (54, 58) | Father- leukemia(70) Brother- prostate(62) | ― | ― | dMMR | MSH2 |  |  | ,A. Canney, et al. [31] |
2 | 64 | M | Colorectum (33, 53) Bladder (51) Sebaceous neoplasms of skin (Muir-Torre syn.) | No | ― | MSI-H | dMMR | MSH2 |  |  | L. Nolan, et al. 2009 |
3 | 68 | M | Colorectum (43, 63, 64) Lung(SCC)(63) Prostate(67) | Mother- uterus Brother- stomach | ― | MSI-H | dMMR | MSH2 |  |  | ,Y. Kawashima, et al. [32] |
4 | 74 | F | No | No | P* | MSS | pMMR | PMS2 | PTCH1 | Yes | .S. Sun, et al. [33] |
5 | 62 | F | No | Mother- colon(40 s) | P | ― | pMMR | MSH2 | MAP2K2, GNAS | Yse | .S. Sun, et al. [33] |
6 | 70-75 |  | No | No | P | MSS | ― | PMS2 | GNAS,EGFR,MTOR,CUL3,CREBBP | No | .S. Sun, et al. [33] |
7 | 55-60 |  | No | Mother- colon | P | MSS | ― | MSH6 | MLL3,EGFR,TP53,RB1,NXF5,CBL | No | .S. Sun, et al. [33] |
8 | 65-70 |  | No | No | P | MSS | ― | MSH6 | IGF1R,TP53,ARID2,XRCC3,MET | No | .S. Sun, et al. [33] |
9 | 75-80 |  | No | Brother- stomach | P | MSS | ― | MSH6 | ALK,LRP1B,TP53,DNMT3A,HRAS,DDR2,NTM,TCF7L2,POLE | No | S. Sun, et al. [33]. |
10 | 50 | M | Lung Stomach | Father- lung Sister- breast | P | ― | ― | MLH1 MSH2 | EGFR, TERT | Yes | .X.Chen et al. [34] |
11 | 36 | M | No | Sister- colorectum (32) Father- colorectum (46, 54) Paternal uncle- clorectum (40) Paternal grandmother-colorectum (41) | ― | MSI-H | dMMR | MLH1 |  |  | K.Masuzawa,et al. 2020 |
12 | 66 | F | Endometorium | No description | T** | MSS | pMMR | MSH2 | EGFR, TP53 | Â | .Hissong et al. [35] |
13 | 74 | F | Ovary Rectum | No | ― | MSI-H | ― | MSH6 |  |  | .Maccaroni et al. [36] |
14 | 76 | M | No | Brother-stomach Sister-colon | P | ― | pMMR | MSH6 | ALK, LRP1B, TP53 | Yes | ,Y. Long, et al. [37] |
15 | 62 | M | No | No | P | MSI-H | dMMR | PMS2 | KRAS, TP53 | Yes | Q Han et al. 2022 |
16 | 70 | F | Colon(51) Urothelium(63) Lung(67) | Father-colon(46) Uncle- colon(58) Brother- pancreas(52) Sister- colon(90),urothelium(70),HCC(80) | T | ― | pMMR | MSH2 |  |  | U.Majeed et al. 2023 |
17 | 62 | F | Colon Tongue | Paternal grandmmother- colon Paternal aunt- colon Son- colon(35) | T | MSS | ― | MLH1 | EGFR | Yes | .A. Hodges et al. [39] |
18 (Our case) | 65 | M | No | Sister- endometrium(39) Father- stomach Mother- tongue | T | MSS | pMMR | PMS2 | TP53, CDKN2A, ERBB2 | No | Our case |
