Fig. 1: NAFLD development is associated with increased TNFα production and dysregulated hepatic glutathione homeostasis. | Experimental & Molecular Medicine

Fig. 1: NAFLD development is associated with increased TNFα production and dysregulated hepatic glutathione homeostasis.

From: Glutathione disulfide sensitizes hepatocytes to TNFα-mediated cytotoxicity via IKK-β S-glutathionylation: a potential mechanism underlying non-alcoholic fatty liver disease

Fig. 1

Male C57BL/6 mice were fed with control and high-fat diets (HFD) for 12 weeks. a Liver TG levels. b Plasma ALT levels. c Histological examination (H&E and Oil Red O staining of liver tissue) and NAFLD histological activity scores. d Plasma TNFα and IL-6 levels. e TNFα levels in hepatic tissues. f GSH and GSSG levels in the liver. g Hepatic GSSG/GSH ratio. h Western blot analysis of long-term HFD feeding on hepatic. 4-HNE-protein adduct formation. Data are expressed as the mean ± SD (n = 6). *p < 0.05 versus control

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