Fig. 4: Effects of TAK-733 on neointimal formation. | Experimental & Molecular Medicine

Fig. 4: Effects of TAK-733 on neointimal formation.

From: TAK-733 inhibits inflammatory neointimal formation by suppressing proliferation, migration, and inflammation in vitro and in vivo

Fig. 4: Effects of TAK-733 on neointimal formation.

a Neointimal formation was visualized using hematoxylin & eosin staining. Scale bar (×100) = 200 µm. Scale bar (×400) = 40 µm. b–d The relative neointimal area, N/M area, and lumen area, respectively; *P < 0.05, **P < 0.01, #P < 0.001. e Immunohistochemical staining of α-SMA (upper panel); scale bar (×100) = 100 µm; PCNA-positive (red color) and DAPI-positive staining (blue color) (lower panel). f The number of PCNA-positive cells were counted using ImageJ; scale bar (×200) = 50 µm; #P < 0.001. g Immunohistochemical staining of ERK (upper panel) and p-ERK (lower panel); scale bar (×200) = 50 µm

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