Fig. 6
Integration of functional association and co-expression networks. a Intersection of the two different networks leads to the identification of two small modules (CCCh1 and CCCh2) connected in the context of general aging and brain aging. CCCh means “Components Connected and Co-expressed in the aging hippocampus”. b Networks starting from each gene or whole genes of CCCh were grown through the iterative addition of the most significant interaction partner until the expanded modules reach100 nodes. The expanded modules starting from individual genes were compared to the expanded module starting from whole genes of CCCh. X axis points to the gene number of expanded modules and Y axis to proportion of overlap between the two expanded modules. Legends in the upper left of the plots correspond to the seed genes (starting individual genes). c Excess retention analysis showed that CCCh1 tends to be located at the periphery of aging module1 (association network or part of interactome) and at the hub of yellow co-expression module. An m-core of x axis means a network consisting of genes with a degree of at least m and is generated by removing the genes with a degree less than m. Y-axis indicates the enrichment of genes with certain properties (in this case, CCCh1 and CCCh2) in each m-core. For example, a set of genes close to or at the hub tend to show an increasing pattern in the analysis but a decrease in genes at the periphery with increasing m values
