Fig. 1: Gastrin regulates paxillin activation and migration of pancreatic cancer cells. | Experimental & Molecular Medicine

Fig. 1: Gastrin regulates paxillin activation and migration of pancreatic cancer cells.

From: Gastrin stimulates pancreatic cancer cell directional migration by activating the Gα12/13–RhoA–ROCK signaling pathway

Fig. 1

a Gastrin dose dependently induces elevated tyrosine phosphorylation of paxillin in PANC-1 cells. b Gastrin time dependently induces elevated tyrosine phosphorylation of paxillin in PANC-1 cells. c 200 nM gastrin treatment for 60 min can activate paxillin in HGC cells. d 200 nM gastrin treatment for 60 min can activate paxillin in HT-29 cells. e, f Gastrin (200 nM) promotes the invasion (e) and migration (f) of PANC-1 cells, as indicated by Boyden chamber assays. g The wound healing assay indicates the elevated migration of PANC-1 cells following 48 h of gastrin stimulation. β-actin was used as a loading control. The values indicate the means ± SD from three independent experiments

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