Fig. 5: miR-192 in donor-cell EVs induced fibrosis in recipient cells. | Experimental & Molecular Medicine

Fig. 5: miR-192 in donor-cell EVs induced fibrosis in recipient cells.

From: Exendin-4 ameliorates high glucose-induced fibrosis by inhibiting the secretion of miR-192 from injured renal tubular epithelial cells

Fig. 5

a Relative expression of miR-192 in HK-2 cells after incubation with EVs derived from NG, HG, exendin-4, and Ex-HG groups for 48 h (*P < 0.05 versus the NG EV group; #P < 0.05 versus the HG EV group). b Relative expression of miR-192 in EVs derived from HK-2 cells pre-transfected with the miR-192 inhibitor or negative control (NC) and exposed to HG for 48 h (*P < 0.05 versus the HG + NC group). c–e Relative expression of miR-192, Col-I, and FN in HK-2 cells after incubation with EVs derived from HK-2 cells pre-transfected with the miR-192 inhibitor or NC and exposed to HG for 48 h. f, g Col-I and FN expression in HK-2 cells after incubation with EVs derived from HK-2 cells pre-transfected with the miR-192 inhibitor or NC and exposed to HG for 48 h was analyzed by western blot (*P < 0.05 and ***P < 0.001 versus the HG + NC EV group)

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