Fig. 4: Topical application of VTI-1002 gel promotes tissue remodeling in diabetic burn wounds.

Representative images of a FBN (fibronectin), b DCN (decorin) staining, and quantification of a FBN, b DCN staining intensity in the wounds at day 30 from vehicle control group and VTI-1002 treatment group (n ≥ 5 per group). Scale bar = 100 µm. c Representative images of Picrosirius Red staining and quantification of staining intensity in the wounds at day 30 from vehicle control group and VTI-1002 treatment group (n ≥ 5 per group). Scale bar = 100 µm. d Representative second-harmonic generation (SHG) imaging and quantification of SHG signal intensity in the wounds at day 30 from vehicle control group and VTI-1002 treatment group (n ≥ 5 per group). Scale bar = 50 µm. e Comparison of type I/III collagen ratio in the wounds at day 30 between vehicle control group and VTI-1002 treatment group (n ≥ 5 per group). f Comparison of post-wound skin tensile strength at day 30 between vehicle control group and VTI-1002 treatment group (n ≥ 5 per group). Results are expressed as median and min/max value, NS = not significant, *P < 0.05, **P < 0.01 by Student's t test