Table 2 The effects of CTS inhibitors on the viability and serum-induced invasion of MDA-MB-231 cells

From: Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis

CTS inhibitor

Concentration

Invasion (% inhibition)

CA-074 Me (nM)

1

22.16 ± 2.58#

 

5

38.49 ± 2.57#

 

25

49.95 ± 1.52#

Pepstatin A (μM)

1

3.81 ± 0.81

 

5

4.49 ± 0.97

 

25

6.17 ± 0.96

Odanacatib (μM)

0.04

16.71 ± 4.91

 

0.2

22.36 ± 4.57#

 

1

25.05 ± 4.28#

Z-FF-FMK (μM)

0.04

3.83 ± 2.33

 

0.2

7.79 ± 2.63

 

1

11.34 ± 2.42#

Z-FL-COCHO (nM)

0.4

38.48 ± 0.92#

 

2

50.05 ± 0.89#

 

10

56.17 ± 0.93#

  1. Values are mean ± S.E.M. of three independent experiments
  2. #P < 0.05 compared to the serum-treated group
Back to article page