Table 1 Hypoxia and sorafenib resistance in HCC
From: Sorafenib resistance in hepatocarcinoma: role of hypoxia-inducible factors
Cell lines/animal models/human samples | Effects on HIF after sorafenib treatment | Global effects | References |
|---|---|---|---|
HCCs from patients HepG2, Huh7, PLC-5, Hep3B, and SK-Hep-1 cells BALB/c mice inoculated with Hep3B or Huh7 and orthotopic Huh7 hepatic tumors | ↑ HIF-1α | ↑ GLUT-1, MDR1, and VEGF Activation of NF-κB | |
Human HCC samples HepG2, SMMC-7721, BEK-7402, Hep3B, and Huh7 cells BALB/c nude mice subcutaneous model with HepG2 cells | ↑ HIF-1α | ↑ GLUT-1, MDR1, and VEGF | |
Sorafenib-resistant Huh7 cells (Huh7R) Tumor xenograft model by subcutaneously injecting Huh7 and Huh7R cells in BALB/c nude mice | ↑ HIF-1α | ↑ Galectin-1 | |
HCC samples HepG2, SMMC-7721, MHCC-LM3, and CSQT-2 cells DEN-induced HCC in C57BL/6 mice Mouse xenograft model derived from SMMC-7721 cells | ↑ HIF-1α | ↑ GLUT-1, HK2, PDK1, LDHA, and VEGF | |
HCC-LM3 and Bel-7402 cells BALB/c nu/nu injected with HCC-LM3 cells | ↑ HIF-1α | ↑ GLUT-1 and HK2 | |
HepG2 and Huh7 cells BALB/c mice with Huh7 subcutaneously injected | ↓ HIF-1α ↑ HIF-2α | Activation of TGF-α/EGFR | |
HepG2 and Huh7 cells BALB/c mice with Huh7 subcutaneously injected | ↓ HIF-1α ↑ HIF-2α | ↑ VEGF and cyclin D1 ↓ LDHA | |
HepG2, Huh7, and SK-Hep-1 cells Mice HCC nodules Orthotopic HCC mouse models with SK-Hep-1 cells | ↑ HIF-2α | ↑ AR | |
HepG2, Huh7, Bel-7402, and SMMC-7402 cells BALB/c mice subcutaneously inoculated with HepG2 | ↓ HIF-1α ↑ HIF-2α | ↑ β-catenin/c-Myc/PCNA | |
HCC cells | ↑ HIF-2α | ̶ | |
MHCC97H cells BALB/c mice subcutaneously injected with MHCC97H cells | ↑ HIF-2α | ↓ TIP30 |
