Fig. 5: The activity of the TWIK-1/TASK-3 concatenated chimera is inhibited by NT–NTSR1 signaling. | Experimental & Molecular Medicine

Fig. 5: The activity of the TWIK-1/TASK-3 concatenated chimera is inhibited by NT–NTSR1 signaling.

From: TWIK-1/TASK-3 heterodimeric channels contribute to the neurotensin-mediated excitation of hippocampal dentate gyrus granule cells

Fig. 5

a–c Averaged I–V relationships in COS-7 cells transfected with TASK-3 and NTSR1 a, TWIK-1 and NTSR1 b, or the TASK-3/TWIK-1 concatenated channel and NTSR1 c, measured before and after the application of 10 μM neurotensin (NT) under a whole-cell configuration. d Summary bar graph showing normalized current density (as in a–c) at +40 mV. All values are means ± SEM (**P < 0.01 and ***P < 0.001). e Summary bar graph showing the inhibition ratio by NT application. All values are means ± SEM (**P < 0.01 and ***P < 0.001). The P-values were obtained with Student’s t-test

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