Fig. 6: Melatonin accelerates wound closure.

a Two rounds of full-thickness dermal wounds were made on both sides of the dorsal trunk. b Representative images of wound closure are shown in the control, control + melatonin, diabetes, and diabetes + melatonin groups on days 0, 3, 7, 14, and 21. c Wound closure rates of the four groups at the indicated times. Data are presented as the mean ± SEM. Significant differences between the treatment and control groups are indicated as **P < 0.01 or *P < 0.05. n = 6