Fig. 5 | Experimental & Molecular Medicine

Fig. 5

From: USP15 inhibits multiple myeloma cell apoptosis through activating a feedback loop with the transcription factor NF-κBp65

Fig. 5The alternative text for this image may have been generated using AI.

USP15 knockdown inhibits tumor growth and related protein expression in MM in vivo. After RPMI 8226 cells were transfected with pLKO.1-USP15-shRNA or the negative control (shNC) and injected into the nude mouse xenograft model, the mice were sacrificed 48 days later, the tumor weight (a, b) and volume (c) were evaluated, and the expression of USP15, Bcl-2, Bcl-xL, Survivin, cleaved Caspase-3 (C-Caspase-3), cleaved PARP1 (C-PARP1), nuclear NF-κBp65, and cytoplasmic NF-κBp65 in xenograft tumors was measured by western blot (d, e). ***P < 0.001 compared with shNC

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