Fig. 6: MiR-34-triple knockout enhances mutant Kras-driven lung tumorigenesis.
From: MiR-34a and miR-34b/c have distinct effects on the suppression of lung adenocarcinomas
a Histologic sections of lung tissues from the miR-34-triple knockout (TKO), Kras-mutant (KrasG12D), and miR-34-TKO/Kras-mutant mice. Lung tissue sections from each cohort were stained with hematoxylin and eosin and photographed. Magnifications of the adenomas are shown in the insets. b Lung histopathology of miR-34-TKO, Kras-mutant, and miR-34-TKO/Kras-mutant mice. P-values were determined using two-tailed Fisher’s exact tests. c Kaplan–Meier plot of lung adenocarcinoma patients from TCGA data. Patients were divided into two groups (high and low) based on the total miR-34 (miR-34a, miR-34b, and miR-34c) expression levels. P-values were determined with the log-rank test
