Fig. 1: Functional domains and substrates of O2- and α-KG-dependent histone demethylases. | Experimental & Molecular Medicine

Fig. 1: Functional domains and substrates of O2- and α-KG-dependent histone demethylases.

From: The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism

Fig. 1

a Substrates for O2- and α-KG-dependent histone demethylases. JHDMs (JmjC domain-containing histone demethylases) remove methyl (CH3-) groups from methylated lysines. JHDMs require O2, α-ketoglutarate, Fe(II), and vitamin C (vit C) for their catalytic activities and release CO2, succinate, and Fe(III). b Schematic illustration of the protein domains of histone demethylases. The domain architecture from the UniProt or NCBI gene (KDM1A, B) information was transformed using https://prosite.expasy.org/mydomains/. The numbers written in each functional domain column indicate the number of amino acids. ARID AT-rich interacting domain, amino oxidase amine oxidase domain, C5HC2 C5HC2 zinc-finger domain, CW CW-type zinc-finger domain, CXXC CXXC zinc-finger domain, C6 C6 zinc-finger domain, JMJC Jumonji C domain, LRR Leu-rich repeat domain, PHD plant homeodomain, SWIRM Swi3p, Rsc8p, and Moira domain, TPR tetratricopeptide domain, TUDOR Tudor domain

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