Table 1 Cancer driver genes involved in epigenetics

Pathways involved in epigenetics	Driver genes	Tumor suppressor/oncogene prediction (by 20/20+^a)	Approved name	Activity	Cancer type^b	Other driver genes in this pathways
Histone modification	KDM6A	tsg	Lysine demethylase 6A, UTX	H3K27me2/3 demethylase	BLCA, HNSC, KIRP, LUSC, PAAD, PANCAN, PRAD	PPP6C
Histone modification	SETD2	tsg	SET domain-containing 2	H3K36 methyl transferase	KIRC, KIRP, LGG, LUAD, MESO, PANCAN	PPP6C
Chromatin histone modifiers	KDM5C	tsg	Lysine demethylase 5C, JARID1C	H3K4me2/3 demethylase	KIRC, PANCAN	ARID5B, CREBBP, EP300, KANSL1, MEN1, NCOR1, NSD1, SIN3A, WHSC1, ZMYM3
	KMT2A	tsg	Lysine methyltransferase 2A	H3K4 methyl transferase	PANCAN
	KMT2B	tsg	Lysine methyltransferase 2B	H3K4 methyl transferase	PANCAN, UCEC
	KMT2C	tsg	Lysine methyltransferase 2C	H3K4 methyl transferase	BLCA, BRCA, CESC, PANCAN, UCEC
	KMT2D	tsg	Lysine methyltransferase 2D	H3K4 methyl transferase	BLCA, CESC, DLBC, ESCA, HNSC, LUSC, PANCAN, PRAD
Chromatin (other)	H3F3A	Possible oncogene	H3 histone family member 3A, H3.3A		PANCAN	AJUBA, ASXL1, ASXL2, ATF7IP, BCOR, CHD3, CHD4, CHD8, CTCF, NIPBL, NPM1
	H3F3C	—	H3 histone family member 3C, H3.5		PANCAN
	HIST1H1E	Possible oncogene	HIST1H1E, H1.4		DLBC
		Possible tsg	HIST1H1E, H1.4		LIHC
Metabolism	IDH1	Oncogene	Isocitrate dehydrogenase (NADP(+)) 1	NADP-dependent IDH, Cytosolic	CHOL, GBM, LAML, LGG, LIHC, PANCAN, PRAD, SKCM	—
Metabolism	IDH2	Oncogene	Isocitrate dehydrogenase (NADP(+)) 2	NADP-dependent IDH, Mitochondrial	LAML, LGG, PANCAN	—

Among the 299 driver genes mentioned by Bailey et al.⁴⁷, only the epigenetics-related pathways have been sorted out
^a20/20+: Classifies genes as an oncogene, tumor suppressor gene, or as a nondriver gene using Random Forests, http://2020plus.readthedocs.org
^bBLCA (bladder urothelial carcinoma), BRCA (breast invasive carcinoma), CESC (cervical squamous cell carcinoma and endocervical adenocarcinoma), CHOL (cholangiocarcinoma), DLBC (lymphoid neoplasm diffuse large B-cell lymphoma), ESCA (esophageal carcinoma), GBM (glioblastoma multiforme), HNSC (head and neck squamous cell carcinoma), KIRC (kidney renal clear cell carcinoma), KIRP (kidney renal papillary cell carcinoma), LAML (acute myeloid leukemia), LGG (brain lower grade glioma), LIHC (liver hepatocellular carcinoma), LUAD (lung adenocarcinoma), LUSC (lung squamous cell carcinoma), MESO (mesothelioma), PAAD (pancreatic adenocarcinoma), PANCAN (Pan-cancer), PRAD (prostate adenocarcinoma), SKCM (skin cutaneous melanoma), THCA (thyroid carcinoma), UCEC (uterine corpus endometrial carcinoma)

Search