Table 2 O2- and α-KG-dependent histone demethylases

From: The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism

Symbol

Synonyms

Chromosome

Histone substrate selectivity130

Mutations in human cancera

KDM1A

AOF2, KDM1, KIAA0601, BHC110, LSD1

1p36.12

H3K4me2/3, H3K9me1/2

UCEC (6.42%), READ (5.11%), BLCA (3.40%)

KDM1B

C6orf193, AOF1, FLJ34109, FLJ33898, dJ298J15.2, bA204B7.3, FLJ43328, LSD2

6p22.3

H3K4me1/2

UCEC (9.06%), STAD (4.77%), COAD (4.75%)

KDM2A

FBXL11, KIAA1004, FBL11, LILINA, DKFZP434M1735, FBL7, FLJ00115, CXXC8, JHDM1A

11q13.2

H3K36me1/2

UCEC (10.94%), CESC (5.54%), COAD (5.00%)

KDM2B

FBXL10, PCCX2, CXXC2, Fbl10, JHDM1B

12q24.31

H3K4me3, H3K36me1/2

UCEC (10.75%), COAD (8.50%), DLBC (8.11%)

KDM3A

JMJD1, JMJD1A, TSGA, KIAA0742, JHMD2A

2p11.2

H3K9me1/2

UCEC (6.98%), STAD (4.77%), BLCA (3.88%)

KDM3B

C5orf7, JMJD1B, KIAA1082, NET22

5q31.2

H3K9me1/2

UCEC (13.58%), SKCM (8.32%), COAD (6.50%)

KDM3C

TRIP8, DKFZp761F0118, KIAA1380, FLJ14374, JMJD1C

10q21.3

H3K9me1/2

UCEC (16.42%), STAD (8.86%), READ (7.30%)

KDM4A

JMJD2, JMJD2A, KIAA0677, JHDM3A, TDRD14A

1p34.2-p34.1

H3K9me1/2/3, H3K36me1/2/3, H1.4K26me1/2/3

UCEC (8.30%), COAD (5.75%), BLCA (3.40%)

KDM4B

JMJD2B, KIAA0876, TDRD14B

19p13.3

H3K9me1/2/3, H3K36me1/2/3, H1.4K26me1/2/3

UCEC (9.43%), COAD (7.25%), STAD (5.91%)

KDM4C

JMJD2C, GASC1, KIAA0780, TDRD14C

9p24.1

H3K9me1/2/3, H3K36me1/2/3, H1.4K26me1/2/3

UCEC (11.13%), STAD (4.09%), LUAD (4.06%)

KDM4D

JMJD2D, FLJ10251

11q21

H3K9me1/2/3, H3K36me1/2/3, H1.4K26me1/2/3

UCEC (6.98%), SKCM (3.20%), COAD (3.00%)

KDM4E

KDM4DL, JMJD2E, KDM5E

11q21

H3K9me1/2/3

UCEC (6.23%), LUAD (1.41%), CESC (1.38%)

KDM5A

RBBP2, JARID1A

12p13.33

H3K4me1/2/3

UCEC (18.87%), STAD (7.27%), SKCM (6.61%)

KDM5B

JARID1B, RBBP2H1A, PLU-1, CT31, PPP1R98

1q32.1

H3K4me1/2/3

UCEC (12.45%), STAD (6.59%), CESC (6.57%)

KDM5C

SMCX, JARID1C, MRX13, DXS1272E, XE169

Xp11.22

H3K4me1/2/3

UCEC (13.21%), STAD (6.36%), KIRC (6.25%)

KDM5D

HYA, HY, SMCY, JARID1D, KIAA0234

Yq11.223

H3K4me1/2/3

READ (2.19%), SKCM (1.71%), STAD (1.59%)

KDM6A

UTX

Xp11.3

H3K27me1/2/3

BLCA (29.37%), UCEC (13.21%), CESC (6.57%)

KDM6B

JMJD3, KIAA0346

17p13.1

H3K27me1/2/3

UCEC (11.32%), SKCM (8.10%), STAD (7.05%)

KDM6C

UTY, KDM6AL

Yq11.221

H3K27me1/2/3

BLCA (2.43%), ESCA (2.17%), READ (1.46%)

KDM7A

JHDM1D, KIAA1718

7q34

H3K9me1/2, H3K27me1/2, H4K20me1/2

UCEC (6.79%), SKCM (5.33%), COAD (5.00%)

KDM7B

ZNF422, JHDM1F, KIAA1111, PHF8

Xp11.22

H3K9me1/2, H4K20me1/2

UCEC (13.77%), SKCM (4.26%), CESC (3.81%)

KDM7C

KIAA0662, CENP-35, JHDM1E, PHF2

9q22.31

H3K9me1/2, H3K27me1/2, H4K20me3

UCEC (14.34%), COAD (6.25%), STAD (6.14%)

KDM8

JMJD5, FLJ13798

16p12.1

H3K36me2/3

UCEC (6.23%), COAD (3.00%), READ (2.92%)

JMJD6

PSR, PTDSR, PTDSR1

17q25.1

H3R2me1, H4R3me1

UCEC (4.91%), READ (3.65%0, DLBC (2.70%)

JMJD7

NA

15q15.1

NA

UCEC (2.64%), CESC (0.69%), SKCM (0.64%)

JMJD8

C16orf20

16p13.3

NA

DLBC (2.70%), UCEC (2.64%), UCS (1.75%)

JMJD9

RIOX1, C14orf169, MAPJD, NO66, ROX, URLC2, hsNO66

14q24.3

H3K4me2/3, H3K36me2/3

UCEC(5.66%), COAD (3.75%), STAD (2.95%)

JMJD10

RIOX2, MDIG, MINA, MINA53, NO52, ROX

3q11.2

H3K9me1/2

UCEC (8.30%), COAD (2.75%), STAD (2.5%)

  1. aIdentified in the Cancer Genome Atlas (TCGA, https://portal.gdc.cancer.gov/). AOF1/2, amine oxidase (flavin-containing) domain 1/2; BHC110, BRAF35-HDAC complex protein; CENP-35, centromere protein 35; CT31, cancer/testis antigen 31; CXXC2/8, CXXC-type zinc finger protein 2/8; Fbl7/10, F-box protein 7/10; FBXL10/11, F-box and leucine-rich repeat protein 10/11; GASC1, gene amplified in squamous cell carcinoma 1 protein; HYA, histocompatibility Y antigen; JARID, Jumonji/AT-rich interaction domain-containing protein; JHDM, Jumonji C domain-containing histone demethylase; JMJD, Jumonji domain-containing; KDM, lysine-specific demethylase; LRR, leucine-rich repeat; LSD1/2, lysine-specific histone demethylase 1/2; MAPJD, MYC-associated protein with JmjC domain; MDIG, mineral dust-induced gene protein; MINA(52/53), MYC-induced nuclear antigen (52/53); NO52/66, nucleolar protein 52/66; PHF2/8, plant homeobox domain finger protein 2/8; PCCX2, protein-containing CXXC domain 2; PPP1R98, protein phosphatase 1, regulatory subunit 98; PSR, phosphatidylserine receptor; PTDSR, Phosphatidylserine receptor; RBBP2, retinoblastoma binding protein 2; RIOX1/2, ribosomal oxygenase 1/2; ROX, ribosomal oxygenase; SMCX/Y, protein SmcX/Y; TDRD14A/B/C, Tudor domain-containing 14A/B/C; TPR, tetratricopeptide repeat; TSGA, testis-specific protein A; URLC2, upregulated in lung cancer 2; UTX/Y, ubiquitously transcribed tetratricopeptide repeat, X/Y chromosome; XE169, Protein Xe169
Back to article page