Table 1 Summary of RNA and DNA viruses and ligand recognition by PRRs
From: Intracellular sensing of viral genomes and viral evasion
PRR | Agonist | Representative virus |
|---|---|---|
RIG-I | 5' ppp dsRNA short dsRNA 5' ppp ssRNA AU-rich 3' UTR RNase L cleavage products Circular viral RNA pU/UC HCV genomic RNA | SeV, NDV, RSV, MV, VSV, IAV, EBOV, JEV, HCV, WNV, DENV, Rotavirus, Vaccinia virus, Adenovirus, Rift Valley fever virus, Lassa virus, Nipha virus, Rabies virus, Influenza B virus |
MDA5 | Long dsRNA RNase L cleavage products AU-rich motifs | ECMV, MV, WNV, SeV, DENV, MHV, HCV, PIV5, EV, Murine norovirus-1, Rabies virus, Saffold virus, Rotavirus, Adenoviruses, Theiler’s virus |
LGP2 | dsRNA | ECMV, VSV, HCV, Poliovirus |
cGAS | RNA:DNA intermediate dsDNA ssDNA Mitochondrial DNA | HSV-1, MHV68, Adenovirus |
IFI16 | dsDNA ssDNA | HSV-1, HCMV, KSHV, EBV |
AIM2 | dsDNA | MCMV, Vaccina virus |
