Fig. 7: Activation of the XBP1s pathway in diet-induced animal models of NAFLD by Sirt6 deficiency. | Experimental & Molecular Medicine

Fig. 7: Activation of the XBP1s pathway in diet-induced animal models of NAFLD by Sirt6 deficiency.

From: Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis

Fig. 7

a Protein levels of XBP1s and CHOP were analyzed in 10-week HFD-fed mice, 4-week MCD-fed mice, and 10-week HFHF-fed mice and in 12-week-old db/db mice. b, c Hepatic TG levels and perilipin immunostaining for lipid droplets were determined. Bars = 10 μm. d, e Protein levels of XBP1s and CHOP were compared in NCD-, HFD-, or HFHF-fed WT and KO mice. The values are the mean ± SEM. *p < 0.05 and **p < 0.01 versus NCD; #p < 0.05 versus WT

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