Fig. 7: Effect of 6SG on the suppression of tumor growth and angiogenesis in tumor-bearing mice.
From: 6′-Sialylgalactose inhibits vascular endothelial growth factor receptor 2-mediated angiogenesis
a Diagram depicting the experimental schedule for growth inhibition of allograft tumors by 6SG. b, d Tumor volume in LLC and CT26 tumor-bearing mice after treatment with 6SG (0, 0.5 or 1.0 mg/kg) on the indicated days (day 0, 8, 11, and 13). c, e The weights of tumors resected from LLC and CT26 tumor-bearing mice on day 14 after treatment with 6SG (0.5 or 1.0 mg/kg). The graph shows the mean ± SD. **P < 0.01 and ***P < 0.001 compared with the control. f Representative images of PECAM1+ vasculature in LLC and CT26 tumors in mice treated with three different doses of 6SG (0, 0.5 or 1.0 mg/kg). Scale bar, 100 μm. g, h Quantitative analysis of the vasculature. The graph shows the mean ± SD. **P < 0.01 and ***P < 0.001 compared with the control
