Table 1 Depletion of Mob1a/b causes early embryonic lethality in mice: (a) The number and genotypes of pups from Mob1a+/−:Mob1b+/− intercrosses. (b) No Mob1a/b-null embryos were observed from Mob1a+/−:Mob1b−/− intercrosses (upper, designated as Mob1b−/− background) or Mob1a−/−:Mob1b+/− intercrosses (bottom, designated as Mob1a−/− background)

From: Loss of Mob1a/b impairs the differentiation of mouse embryonic stem cells into the three germ layer lineages

(a)

Mob1a

Mob1b

No. (%) of mice

 

+/+

+/+

4 (2.8)

 

+/−

+/+

12 (8.5)

 

−/−

+/+

6 (4.2)

 

+/+

+/−

19 (12.8)

 

+/−

+/−

36 (25.7)

 

−/−

+/−

26 (18.5)

 

+/+

−/−

10 (7.1)

 

+/−

−/−

18 (20.0)

 

−/−

−/−

0 (0)

 

(b)

 

+/+

+/−

−/−

E8.5d (Mob1b−/− background)

4

8

0

E10.5d (Mob1a−/− background)

6

10

0