Table 1 Depletion of Mob1a/b causes early embryonic lethality in mice: (a) The number and genotypes of pups from Mob1a+/−:Mob1b+/− intercrosses. (b) No Mob1a/b-null embryos were observed from Mob1a+/−:Mob1b−/− intercrosses (upper, designated as Mob1b−/− background) or Mob1a−/−:Mob1b+/− intercrosses (bottom, designated as Mob1a−/− background)
(a) | |||
|---|---|---|---|
Mob1a | Mob1b | No. (%) of mice | |
+/+ | +/+ | 4 (2.8) | |
+/− | +/+ | 12 (8.5) | |
−/− | +/+ | 6 (4.2) | |
+/+ | +/− | 19 (12.8) | |
+/− | +/− | 36 (25.7) | |
−/− | +/− | 26 (18.5) | |
+/+ | −/− | 10 (7.1) | |
+/− | −/− | 18 (20.0) | |
−/− | −/− | 0 (0) | |
(b) | |||
|---|---|---|---|
+/+ | +/− | −/− | |
E8.5d (Mob1b−/− background) | 4 | 8 | 0 |
E10.5d (Mob1a−/− background) | 6 | 10 | 0 |