Fig. 3: Characteristics and roles of STAT2 domains.
From: Stat2 stability regulation: an intersection between immunity and carcinogenesis
Each STAT2 domain plays a specific role in homo- or heterodimerization and ISG expression. The diverse stimuli from outside or inside cells induce posttranslational modifications such as phosphorylation and ubiquitination to induce structural changes, parallel or anti-parallel oriented homo- or heterodimers, nuclear or cytosolic localization, and DNA binding.
