Table 1 The expression of tumor-derived DAMP proteins in various tumor types.
From: Interactions between tumor-derived proteins and Toll-like receptors
DAMPs | Tumor type | Function | Reference |
|---|---|---|---|
HMGB1 | Prostate cancer Malignant mesothelioma Hepatocellular carcinoma Colon carcinoma Pancreatic adenocarcinoma Mammary carcinoma Fibrosarcoma Lymphoma Osteosarcoma Melanoma Lewis lung carcinoma | Inducing adaptive immune response Cell migration and proliferation Angiogenesis Metastasis, chemoresistance Escape of apoptosis Tumor-antigen processing Presenting tumor antigen Trigger sterile inflammation Progression of tumors Neutrophil recruitment Increase autophagy | |
S100s | Breast cancer Fibrosarcoma Neuroblastoma Colon cancer Colorectal adenocarcinoma | Cell growth Myeloid cell infiltration Epidermal hyperplasia Secretion of pro-inflammatory cytokines Metastasis | |
HSPs | Breast cancer Colorectal cancer Melanoma | Involve in protein folding Activate immune response Metastasis | |
Histones | Pancreatic cancer Lung cancer | Chromatin remodeling Gene transcription Neutrophil migration Endothelial injury | |
PAUF | Pancreatic cancer Ovarian cancer | Pancreatic tumor development TLR4 stimulation Tumorigenesis Chemoresistance | |
API5 | Adenocarcinoma Cervical cancer Breast cancer | Apoptosis inhibition Activating immune cells | |
RPS3 | Adenocarcinoma Colorectal cancer Melanoma | Translation initiation Repair of UV-induced DNA damage Adjuvant for DC-based vaccine |
