Table 3 The expressions and functions of TLRs in various tumors.
From: Interactions between tumor-derived proteins and Toll-like receptors
Tumor type | TLR type | Function | Reference |
|---|---|---|---|
Ovarian cancer | TLR 2–5, 9 | Immunosuppression Tumor growth Increased migration Resistance to chemotherapy | |
Cervical cancer | TLR 3–5, 7, 9 | Tumorigenesis Tumor growth Resistance to chemotherapy | |
Lung cancer | TLR 2–4, 9 | Prolong cancer cell survival Immune escape Apoptosis resistance Tumor metastasis | |
Colorectal cancer | TLR 2–5, 9 | Tumorigenesis Antitumor activity Cancer proliferation Angiogenesis Inhibit tumor necrosis | |
Melanoma | TLR 2–4 | Tumor migration Tumor progression Prolong cancer cell survival | |
Breast cancer | TLR 2–4, 9 | Tumor invasion | |
Brain cancer | TLR 2, 4 | Tumor progression Tumor metastasis | |
Prostate cancer | TLR 4, 9 | Tumor invasion Carcinogenesis | |
Gastric cancer | TLR 2, 4, 5, 9 | Tumor growth, invasion, and metastasis Angiogenesis Attenuate antitumor activity |
