Fig. 1: Schematic representation of LSD1 and LSD2 class I demethylases.
From: LSD1: more than demethylation of histone lysine residues
a Cognate domains in each enzyme are reported with identical colors to highlight the similarities. b The pathway of lysine demethylation shows the formation of H2O2 and formaldehyde as side products and the imine intermediate that requires protonated lysine and accounts for the inability of LSD1 to demethylate trimethyl residues. c Graphic representation of the LSD1 interaction with the SANT2 domain of CoREST (adapted from ref. 25).
