Fig. 7: Model of the hypothetical transmission mechanisms of Gilz alterations observed from the first generation (F1) to the third generation (F3).
From: Preterm birth is associated with epigenetic programming of transgenerational hypertension in mice
Potential differential parallel induction of Gilz alterations in somatic cells and germ cells in F1 mice. Considering the germ cell-mediated mode of transmission, these alterations were found in all investigated organs (kidney, brain, and lung) in the F2 and F3 males. These Gilz alterations were associated with the transmission of dysregulated blood pressure up to the third generation after a premature birth. LPS: lipopolysaccharides, E18: 18 days of gestation, D0: first day of life, M6: 6 postnatal months, WT: wild type, F1: first generation, F2: second generation, F3: third generation.
