Fig. 2: Inhibition of Wnt/β-catenin signaling activity by targeting the TMEM9-v-ATPase axis. | Experimental & Molecular Medicine

Fig. 2: Inhibition of Wnt/β-catenin signaling activity by targeting the TMEM9-v-ATPase axis.

From: Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

Fig. 2

TMEM9 expression is highly increased in CRC. As an amplifier of Wnt/β-catenin signaling, TMEM9 facilitates the assembly of v-ATPase, resulting in vesicular acidification and subsequent lysosomal degradation of APC. Then, the increased β-catenin transactivates Wnt target genes. The inhibition of TMEM9-v-ATPase-induced vesicular acidification by bafilomycin and concanamycin efficiently inhibits APC lysosomal degradation, which leads to the suppression of Wnt/β-catenin gene activation in cancer cells.

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