Fig. 7: Proposed underlying mechanism of action of lncRNA NEAT1 in the apoptosis and proliferation of hepatocytes in FHF. | Experimental & Molecular Medicine

Fig. 7: Proposed underlying mechanism of action of lncRNA NEAT1 in the apoptosis and proliferation of hepatocytes in FHF.

From: Long noncoding RNA NEAT1 suppresses hepatocyte proliferation in fulminant hepatic failure through increased recruitment of EZH2 to the LATS2 promoter region and promotion of H3K27me3 methylation

Fig. 7

In FHF hepatocytes, lncRNA NEAT1 recruits EZH2 to the promoter region of LATS2 and induces the production of H3K27me3, thus repressing the expression of LATS2. Upon inhibition of the LATS2 expression, YAP1 could not be activated and enter the nucleus, which results in binding to P73 and induces the apoptosis mediated by P73.

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