Fig. 8: Proposed mechanism of the protective action of lipin-1 inhibition against UVB-induced proinflammatory responses. | Experimental & Molecular Medicine

Fig. 8: Proposed mechanism of the protective action of lipin-1 inhibition against UVB-induced proinflammatory responses.

From: UVB-dependent inhibition of lipin-1 protects against proinflammatory responses in human keratinocytes

Fig. 8

UVB radiation inhibits lipin-1 expression in NHEKs. This inhibition is mediated by the AMPK-JNK-SREBP-1 signaling axis. Lipin-1 inhibition suppresses UVB-induced IL-6 and IL-8 production. The anti-inflammatory effect of lipin-1 repression may be attributed to the suppression of NF-ĸB signaling and FFA accumulation.

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