Fig. 4: The overall molecular mechanisms underlying the β-HB-associated effects on aging.
From: β-hydroxybutyrate and its metabolic effects on age-associated pathology
Target molecules and cellular signaling of β-HB are associated with the aging process, which is accelerated by senescence and inflammation. β-HB delays senescence via HDAC inhibition, hnRNP A1-mediated Oct4 expression, and β-hydroxybutyrylation on p53. Furthermore, β-HB suppresses inflammation by NLRP3 inhibition or HCAR2 activation and reduces the contribution to aging-associated diseases.
