Fig. 2: Increased firing frequency in the CA1 pyramidal cells from the PRMT7 KO mice. | Experimental & Molecular Medicine

Fig. 2: Increased firing frequency in the CA1 pyramidal cells from the PRMT7 KO mice.

From: PRMT7 deficiency causes dysregulation of the HCN channels in the CA1 pyramidal cells and impairment of social behaviors

Fig. 2

a Representative traces in the whole-cell current clamp recording in the mature WT and PRMT7 KO CA1 pyramidal cells in response to 1-s depolarizing current injection (from 100 to 250 pA, +50-pA increment, during 1-s). b The mean number of action potentials (AP no.) plotted against the eliciting currents. At all amplitudes, the mean ± S.E.M. AP no. is significantly higher in the PRMT7 KO pyramidal cells (red circles; n = 7) than in the WT pyramidal cells (black circles; n = 11). c–e The mean value of the threshold potential (c), the input resistance (d), and the resting membrane potential (e) in the WT and PRMT7 KO CA1 pyramidal cells. *p < 0.05; **p < 0.01; ***p < 0.001; Student’s t test.

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