Fig. 1: Diet-derived microbial metabolites.

Intestinal microbiota can secrete diet-derived metabolites, which can potentially activate the immune system through Ahr, GPRs or GPBAR1. Ahr Aryl hydrogen receptor, BCFA branched chain fatty acid, GPBAR1 G protein–coupled bile acid receptor 1, GPR G-protein-coupled receptor, SCFA short-chain fatty acids, TMA trimethylamine, TMAO trimethylamine N-oxide.