Fig. 1: Schematic depiction of purinergic receptors coupled with Gα12/13 and physiological events. | Experimental & Molecular Medicine

Fig. 1: Schematic depiction of purinergic receptors coupled with Gα12/13 and physiological events.

From: Gα12/13 signaling in metabolic diseases

Fig. 1: Schematic depiction of purinergic receptors coupled with Gα12/13 and physiological events.

Intracellular ATP or UDP is released through Pannexin 1 channels. Extracellular ATP or UDP binding to the purinergic P2Y6 receptor in cardiomyocytes mediates mechanical stretch-induced Gα12/13 and Rho activation. P2Y6-Gα12/13 signaling is critical for mechanical stretch-induced fibrotic factors such as connective tissue growth factor (CTGF), periostin and transforming growth factor (TGF)-β. Extracellular ATP is actively broken down to ADP, AMP and, ultimately, adenosine by ectonucleotidases and may serve as GPCR ligands. Gα12 is involved in the fatty acid oxidation process downstream of adenosine receptors.

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