Table 1 List of molecules involved in LPC activation and their expressing cell types.
Molecular function or signaling pathway | Molecule | Expressing cell type | References |
|---|---|---|---|
Cytokine | IFNγ | LPC | |
IL-6 | Inflammatory cell | ||
DNA demethylation | TET1 | LPC | |
FGF signaling | FGF7 | Thy1+ mesenchymal cell | |
FGFR2 | LPC | ||
FGFBP1 | LPC | ||
HGF/c-Met signaling | c-Met | LPC | |
HGF | HSC | ||
IL-6/STAT3 signaling | SOCS3 | LPC, inflammatory cell, hepatocyte | |
Integrin signaling | Galectin-3 | LPC, hepatocyte, macrophage | |
mTOR signaling | Ribosomal S6 | LPC | |
NF-kB signaling | NF-kB | LPC, hepatocyte | |
TGF signaling | GDF11 | HSC | |
TGF-β | HSC | ||
β2-spectrin | LPC | ||
TGF-β type II receptor | LPC | ||
Shh signaling | Gli2 | LPC, hepatocyte | |
Ihh | Hepatocyte | ||
TNF signaling | Cox2 | LPC, Kupffer cell, endothelial cell | |
LTβ | LPC, inflammatory cell | ||
FN14 | LPC | ||
TWEAK | Macrophage | ||
TNFα | LPC, inflammatory cell | ||
VEGF signaling | VEGFA | Hepatocyte | |
VEGFC | Hepatocyte | ||
VEGFR1 | LPC | ||
VEGFR3 | LPC |
