Fig. 3: The antinociceptive effects of D1DR and D2DR antagonists were abolished by pretreatment with D1DR, D2DR, and D1–D2DR complex agonists in CCI rats. | Experimental & Molecular Medicine

Fig. 3: The antinociceptive effects of D1DR and D2DR antagonists were abolished by pretreatment with D1DR, D2DR, and D1–D2DR complex agonists in CCI rats.

From: The dopamine D1–D2DR complex in the rat spinal cord promotes neuropathic pain by increasing neuronal excitability after chronic constriction injury

Fig. 3

a–c The time course of the MWTs and TWLs of CCI rats after coadministration of the D1DR agonist SKF 38393 (2 μg/20 μL, i.t.), D2DR agonist quinpirole (2 μg/20 μL, i.t.), and D1–D2DR heteromer agonist SKF 83959 (2 μg/20 μL, i.t.) with the D1DR antagonist SCH-23390 (20 μg/20 μL, i.t.). d–f The time course of the MWTs and TWLs of rats with CCI after coadministration of the D1DR agonist SKF 38393 (2 μg/20 μL, i.t.), D2DR agonist quinpirole (2 μg/20 μL, i.t.), and D1–D2DR heteromer agonist SKF 83959 (2 μg/20 μL, i.t.) with the D2DR antagonist L-741,626 (20 μg/20 μL, i.t.) (n = 6; ###P < 0.001 vs the control group; *P < 0.05, **P < 0. 01, ***P < 0.001 vs the CCI group; $P < 0.05, $$P < 0.01 vs the D1DR and D2DR antagonist group).

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