Fig. 4: Antagonizing spinal D1DR and D2DR restrained the activation of PKC γ, CaMKII, MAPK, and CREB in CCI rats. | Experimental & Molecular Medicine

Fig. 4: Antagonizing spinal D1DR and D2DR restrained the activation of PKC γ, CaMKII, MAPK, and CREB in CCI rats.

From: The dopamine D1–D2DR complex in the rat spinal cord promotes neuropathic pain by increasing neuronal excitability after chronic constriction injury

Fig. 4

a, b Western blotting showing the phosphorylation levels of PKC γ, CaMKII, CREB, JNK, p38, and ERK in the spinal cord after intrathecal administration of SCH-23390 (20 μg/20 μL, i.t.) and L-741,626 (20 μg/20 μL, i.t.). c, d Western blotting showing the expression of p-PKC γ, p-CaMKII, p-CREB, p-p38, p-ERK, and p-JNK in the spinal cord after intrathecal injection of D1DR and D2DR siRNA (1 μg/20 μL, i.t.) (n = 4; ###P < 0.001 vs the control group; *P < 0.05, **P < 0.01, ***P < 0.001 vs the CCI group).

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