Fig. 4: INS+ cells in ducts are not fully functional beta-cells.
From: Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy
a The small proportion of Tomato+/CFDA-SE-labeled duct cells purified by FACS was then reaggregated overnight and subjected to a glucose tolerance test. Compared to Tomato+ cells purified from G16 islets, Tomato+ cells purified from CFDA-SE+ duct cells from G16 mouse pancreas exhibited much lower basal INS release and almost no glucose-stimulated INS release. b RT-qPCR for INS, Glut2, and MafA in FACS-purified beta-cells. *P < 0.05; N = 5.
