Fig. 5: PD prevents membrane fusion, as evidenced by the reduced frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) in CA1 neurons. | Experimental & Molecular Medicine

Fig. 5: PD prevents membrane fusion, as evidenced by the reduced frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) in CA1 neurons.

From: Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion

Fig. 5

a Experimental schematic of sIPSC recording in the CA1 hippocampus. b Representative traces of sIPSCs recorded from the CA1 hippocampus before 10 μM PD treatment (left) and during 10 μM PD bath application (right). c Running frequency during 1 h of 10 μM PD treatment. sIPSC events were binned for 1 min to represent the frequency in Hz. d Running average amplitude during 1 h of 10 μM PD treatment. sIPSC amplitudes were binned for every minute. e Representative traces of sIPSCs recorded from the CA1 hippocampus in control, 0.3, 3, and 30 μM PD-treated slices. f Normalized responses for the frequencies (black) and amplitudes (blue) of sIPSCs in the control (n = 15), 0.3 μM (n = 8), 3 μM (n = 9), and 30 μM (n = 6) PD treatment groups. The control condition data (0 μM) were not represented but were included in the nonlinear fitting.

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