Fig. 1: Species differences in IL-30 and IL-27 biogenesis.
From: IL-30† (IL-27A): a familiar stranger in immunity, inflammation, and cancer
a The biogenesis of human (h) IL-27 is shown. Human IL-30 depends on assembly with Ebi3 to fold, be released from the endoplasmic reticulum (ER) chaperone Bip and function once outside the cell. If it remains unpaired, it is degraded by ER-associated degradation (ERAD). b In contrast, murine (m) IL-30 has two structurally adjacent cysteines c that can form a disulfide bond, so murine IL-30 can fold and be secreted in isolation or as a pair with Ebi3.
